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Career Development Sessions for Registration

CAREER DEVELOPMENT SESSION DETAIL

The ISTH Career Development Sessions are targeted towards clinical and research fellows, postdoctoral researchers, as well as faculty in the early stages of their career. Each small group will consist of young investigators with similar career interests allowing them to meet with you, a leader in the field and a well-known and established investigator. Attendees will have the opportunity to ask questions about the topic or discuss scenarios they have encountered on the topic, get career advice and even establish life-long connections, an important aspect of the ISTH.

 

Situated in small groups of 10 attendees per session, you will be asked to give a short introduction (5 minutes) to help break the ice and get everyone comfortable, after which there will be an informal and interactive exchange of questions and discussion. NO audio visual or slide presentations are needed for these interactive sessions. Attendees will be required to pre-book their spot for each class.

 

The Career Development Sessions will be on the afternoons of Sunday, July 10 – Tuesday, July 12 from 13:15 – 14:00 at the ExCel London.

 

Sunday, July 10

13:15 – 14:00

 

John Pasi & Gowthami Arepally – How To Make an Academic/Clinical Job Interview Successful

John Pasi: Lifelong career in clinical/academic medicine, moving for service to academic posts. Educational supervisor/mentor to colleagues who have pursued successful careers in academic medicine. Recent move to industry based on academic career.

Gowthami Arepally: I am in senior leadership positions at Duke. I have participated in numerous faculty searches and faculty interviews. I also conduct a Career Seminar Series where we discuss this topic.

 

Thomas Renné & Tessa Barrett – How to Successfully Apply for Your Next Academic Position

Thomas Renné:

- The first or second postdoctoral position or independent group-leader position is really critical for a successful scientific career and requires preparation.

- It is rewarding to know and learn about the key elements of an appealing and successful application letter.

- A carefully prepared interview is essential for a successful application: what are the key elements to prepare and to consider?

- Applicants should know and learn how to present themselves, their research and their proposed research plan(s) in the most successful manner.

- Learn about other elements that – in addition to excellence in science – contribute to the success of an application.

 

Tessa Barrett: Dr. Barrett received her PhD from the University of Sydney in 2013, and then pursued postdoctoral training at NYU School of Medicine in New York, USA. With research interests in atherosclerosis and thrombosis, Dr. Barrett in 2022 joined the NYU Cardiovascular Research Center as a tenured-track Assistant Professor. Over the last 10 years, Dr. Barrett has gained insight and experience relevant to interviewing, and preparing research statements across various levels in academic science.

 

Lauren G. Poole & Yacine Boulaftali – Tips for Your First Grant Proposal Application

Lauren G. Poole: I am a postdoctoral research associate currently seeking to transition to an independent faculty position. During my postdoctoral training period, I have received two career development awards, including an individual fellowship (F32) and Pathway to Independence Award (K99/R00) from the National Institute of Health. I also have experience with preparation of pre-doctoral training fellowships, both from the NIH and private foundations. I am happy to discuss any aspect of preparing a career development award, from identifying mentors to preparing a clear research plan. This discussion will not be limited to specific awards or funding institutions, so bring any questions you might have!

 

Yacine Boulaftali:

- Great writing in an exciting time to think about project.

- Practice as much as you can and never give up.

- Observe and learn from your mentor.

- Talk to colleagues/friends to challenge your idea.

- Address questions with innovative methods.

- Read as many papers you can to develop your own idea/niche.

- Think outside of your field.

 

Beverley Hunt & Alisa S. Wolberg – Women at the Top: Building a Scientific Career

Alisa Wolberg is a Professor of Pathology and Laboratory Medicine at the University of North Carolina at Chapel Hill. Beverley Hunt is Professor of Thrombosis & Haemostasis at Kings Healthcare Partners on London UK. Both of us have had many publications, sit on numerous national & international committees and have excellent grant income, teach, work with not-for-profit organisations, as well as being active clinicians and/or scientists. Neither of us started out our medical careers with a “plan,” and each of us have had very different careers. Both of us are still learning how to say “no”; have had to deal with challenging situations along the way; both of us have had hard times; but both of us have tried to stay true to ourselves and found both intellectual and emotional fulfilment and feel we have contributed to advancing science and medicine. We aim to have an honest and frank discussion about how to have an academic career in 2022.

 

Monday, July 11

13:15 – 14:00

 

Carsten Deppermann & Julie Rayes – How To Start Your Own Lab

Carsten Deppermann: I have been a Group Leader from 2019-2021 where I established my laboratory as part of the Institute for Clinical Chemistry at UKE, Hamburg. In early 2021, I was appointed Assistant Professor at the Center for Thrombosis and Hemostasis, Mainz. I started building my laboratory; Identifying what you need, which machines and techniques are available, buying equipment, hiring PhD students, a technician, setting up protocols, building networks.

 

Julie Rayes:

- I started my lab 2 years ago.

- I hold multiple grants and would discuss how to write a grant.

- I will talk about transition from post doc to PI.

- I will talk about student supervision.

 

 

Nicola Mutch & Ecaterina Scarlatescu – The Science Behind the Work Life Balance

Nicola Mutch: I am a discovery scientist with a PhD in the field of Thrombosis & Haemostasis. I manage a laboratory of 10-12 individuals of various stages of study and several research technicians/lab managers. I have supervised 9 PhD students; 17 MSc students; 6 MRES and >30 undergraduate students to completion. I have exceptionally busy family life with 4 children ranging from 13 down to 2.5 years. I enjoy exercise, travel and good food and like to spend time exploring new places with my family.

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Ecaterina Scarlatescu: The task of maintaining work and life balance was extremely difficult for me as I tried to build up a career. In the situation of a clinician also trying to perform research in a country which does not provide any support for this, it is a real challenge to maintain this balance and I am not sure I succeeded at all times. And, of course, on must accept that, depending on the situation, at one moment the balance inclines temporarily to one side. But probably the most important thing is to really enjoy what you are doing in such a way that in the end the extra tasks you perform do not feel like work anymore. This is the key thing to avoid burnout, at least the one which worked for me until now.

 

Patricia Liaw – Presenting Your Paper: How To Write a Good Cover Letter for an Article Submission

Patricia Liaw: As a researcher in academia, I have published over 85 peer-review articles and have reviewed over 150 manuscripts for journals such as the Journal of Thrombosis and Haemostasis, Blood, and Critical Care Medicine. Since 2018, I have served as an Associate Editor for the Journal of Thrombosis and Haemostasis. My responsibilities include assigning reviewers to submitted articles, making recommendations on the submissions, and mediating appeals when necessary. An important aspect of the peer-review process is the submission of a good cover letter for the first submission as well as for subsequent revisions.

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Matthew Harper – How To Improve Your Poster

I have been presenting posters at national and international conferences – including ISTH – for nearly 20 years.

 

Tuesday, July 12

13:15 – 14:15

 

Alessandra Balduini – Time Management: How To Use Your Time Productively

As Professor of Medicine, I trained and supported tens of undergraduate and graduate students and post-doc in their career. I took part and promoted many international exchange programs and fellowships for PhD students and post-doc. I have supported many young researchers in obtaining their first grants. I am currently trained by the European Innovation Council, Women Leadership Program (EIC-WLP).

 

James Luyendyk – How To Prepare a Good Elevator Pitch

- Interdisciplinary scientist who has established collaboration in multiple fields (hemostasis/thrombosis, hepatology, toxicology).

- Enthusiastic and approachable scientists with a passion for sharing new ideas.

- Leadership roles involving crafting and selling scientific and professional ideas (P&T Committee, Society of Toxicology Council, Faculty mentor, NIH grant PI, summer undergraduate program PI).

- Involvement in similar programs at MSU focused on “selling your ideas” and quick, focused presentation styles emphasizing key ideas.

- Applies practical approaches to getting your audience (perhaps of 1) interested to hear what’s next.

 

Yotis Senis & Joshua Muia – Changing Country & Changing/Moving Lab

Yotis Senis:

- Born, bred in Canada. Greek ancestry. Dual nationality (Canadian/Greek).

- BScH (Life Sciences, 1989-1993), MSc (Pathology, 1994-1996), PhD (Pathology, 1997-2002).

- Postdoctoral researcher (2002-2004), Pharmacology, University of Oxford, UK.

- British Heart Foundation Basic Research Fellow (2008-2017) at Univeristy of Birmingham, UK.

- Professor of Cellular Haemostasis (2013-2019), University of Birmingham, UK.

- Inserm Director of Research

 

Joshua Muia: Originally from Kenya, moved to United States as a graduate student, transitioned to postdoc and a faculty position. In 2019, my contract on a non-tenured position ended; put myself on job market on a very short notice. In 2020, obtained a tenure-track position and moved my laboratory in the middle of the pandemic to a new institution. I was able to set up the laboratory in the new institution with under COVID-19 restrictions. Everything has challenges but being a member of a minority racial group in the US, it can be very tough in higher Ed. Despite challenges, I have successfully published outstanding work, received awards and secured funding.

 

Renee Eslick – Overcoming Imposter Syndrome

Imposter syndrome is a common problem, particularly for younger female clinicians and researchers, and is certainly is a problem that I have encountered in my own career. I have previously discussed techniques to overcome this with a performance coach and try to share these strategies with the doctors-in-training that supervise.

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Master Class Sessions for Registration

 

MASTER CLASS SESSION DETAIL

The ISTH Master Class Sessions are specifically targeted towards Early Career and Reach-the-World attendees. These sessions will allow them to meet with you, a leader in the field and a well-known and established investigator. Attendees will have the opportunity to ask questions about the topic or discuss scenarios they have encountered on the topic, get career advice and establish life-long connections, an important aspect of the ISTH.

 

The Master Classes will be held on the afternoons of Sunday, July 10 – Tuesday, July 12 from 13:15 – 14:00 at the ExCel London. Situated in small groups of 25 attendees per session, you will be asked to give a short introduction (5 minutes) to help break the ice and get everyone comfortable, after which there will be an informal and interactive exchange of questions and discussion. NO audio visual or slide presentations are needed for these interactive sessions. Attendees will be required to pre-book their spot for each class.

 

The Master Class Sessions will be on the afternoons of Sunday, July 10 – Tuesday, July 12 from 13:15 – 14:00 at the ExCel London.

 

Sunday, July 10

13:15 – 14:00

 

Robert Storey – Antithrombotic Therapy in Atherosclerotic Disease (Clinical)

I have performed preclinical and clinical studies on a broad range of antiplatelet and anticoagulant drugs over the last 25 years. I was chair of the European Society of Cardiology (ESC) Working Group on Thrombosis 2012-2014. I have led on antithrombotic therapy guideline recommendations in ESC guidelines on chronic and acute coronary syndromes. I have served on the steering committees of numerous pivotal trials of antiplatelet therapy.

 

Owen McCarty – Contact Pathway (Basic)

• Developed reagents targeting contact pathway.

• Developed clinical trials targeting contact pathway.

• Discovered pathways regulating contact factor activation

• Authored reviews and papers on topic.

• Mentored trainee research on the topic.

 

 

Fraser Macrae – The Role of Fibrin(ogen) In Thrombosis and Wound Healing (Basic)

I began working for Professor Robert Ariens in 2012 as a research assistant exploring the relationship between abdominal aortic aneurysms and changes in fibrin clot structure. I went on to undertake a PhD focusing on role of fibrin clots in cardiovascular disease and infection. In 2019 I was awarded a Sir Henry Wellcome Fellowship to explore the role of fibrin films in infection and wound healing. In 2020 I became a University Academic Fellow to continue exploring the multifaceted role of fibrin(ogen) in thrombosis and tissue repair.

 

Catherine P.M. Hayward – Bleeding with Normal Laboratory Results (Clinical)

As a Hematologist and Head of our Regional Specialized Coagulation Laboratory, I encounter patients with bleeding and normal laboratory results frequently. This raises questions about minimal investigations needed to diagnose bleeding disorders, and which tests have the highest yield. Another important consideration is what disorders could have been missed by the investigations completed to that point. Rare bleeding disorders also need consideration, with practical strategies on how certain disorders will be ruled in and out. There are also practical considerations for when to diagnose a patient’s problems as a bleeding problem a disorder of unknown cause.

 

Benoît Ho-Tin-Noé – Vascular Integrity and Inflammation (Basic)

After having shown that platelets continuously maintain vascular integrity in inflamed organs and solid tumors using various models of acute inflammation and of cancer in mice. I have used various models to investigate and highlight the mechanisms used in their function. I am an author of several original studies and review articles on this topic.

 

Suely Rezende – Managing VTE in the Developing World (Clinical)

• Chair of the Regional Training Center of ISTH in Brazil

• Panel member of ASH VTE guidelines.

• Panel member of ASH VTE guidelines for Latin America.

• Works in the outpatient’s clinic of anticoagulation

• Works with residents of Hematology in the field of Thrombosis and Hemostasis.

• Leads the team medicine care on anticoagulation.

 

Nichola Cooper – Treatment Decisions in Pediatric ITP (Clinical)

• I run the paediatric I.T.P. center at Imperial College.

• I run observational and interventional clinical trials in paed I.T.P.

• I run a research laboratory investigating genetic and acquired causes of I.T.P. and other disorders.

• I have published guidelines on management of ITP.

• I am a trustee in the UK and USA patient supporters.

 

Peter Lenting – Biochemistry of VWF (Basic)

Over the last 33 years I have been studying the biochemistry of the von Willebrand factor/factor VIII complex. These studies included the identification of conformation-specific antibodies, location of ligand binding sites, the location of receptor-binding sites, expression of recombinant variants both in vitro and in vivo, etc. Many of the studies involved biochemical, cellular and in vivo models.

 

David Stegner – Studying Thrombus Formation Using Light-Sheet and Expansion Microscopy (Basic)

Light-sheet fluorescence microscopy enables imaging big samples, thus providing cellular context without cutting artifacts. We capitalized on this imaging modality to reveal that thrombopoiesis is spatially regulated by the bone marrow vasculature. In addition, we have studied cerebral thrombus formation in the context of ischemic stroke or cerebral venous thrombosis. Expansion microscopy enhances the resolution by expanding the biological samples. We have used this technique to investigate the distribution of platelet GPIIb/IIIa receptors.

 

Monday, July 11

13:15 – 14:00

 

Peter Collins & Rachel Collis - Modern Hemostatic Management of Obstetric Hemorrhage (Clinical)

Peter Collins:

• Longstanding research interests in field.

• Focus of role is point of care haemostatic tests and early fibrinogen replacement.

• Clinical experience of obstetric bleeding over many years.

• Translation of research findings into national initiatives to reduce bleeding and need for blood transfusions.

• Introduction of research findings into national and international guidelines.

 

Rachel Collis: I have been a consultant anesthetist with an interest obstetric anesthesia for 25 years. I have published on the management of PPH for over 10 years. My research of VHA and coagulation replacement in PPH. I led on a large quality research program across all 12 maternity units in Wales with improved outcomes and a recovered use of blood products.

 

Tilman Hackeng – Anticoagulant Regulation of Coagulation Onset (Basic)

               My group has extensive experience and output on anticoagulant factors that regulate (unwanted) onset of coagulation, and has discovered the essential TFPI-cofactor activity of protein S. Regulation of anticoagulation of TFPI is influenced by multiple plasma proteins, and is subject to variation of the latter by genetic or acquired traits resulting in changes in levels or (alternative) forms. We have developed assays to study protein mechanisms and measure levels of diverse forms of anticoagulant factors that contribute to protection against thrombosis.

 

Suzanne Cannegieter – Risk Scores for Thrombotic Conditions (Clinical)

               My research group has been involved in the development, validation and implementation of several risk scores in predicting risk of VTE in a diverse range of clinical conditions.

 

Craig Jenne – Studying Thromboinflammation by Multi-Color Intravital Microscopy (Basic)

Applying intravital imaging has allowed us to map dynamic interactions between leukocytes, platelets, and pathogens. Additional development of protease activatable probes has allowed us to understand how these processes lead to thrombin generation and the initiation of coagulation within the context of infections and inflammation. These studies have shed new insight into the contribution of platelets to immunity and the impact of immunothrombosis to disease pathology.

 

Claire Whyte – Flow Models of Fibrinolysis (Basic)

My research focuses on fibrinolysis and the role of platelets in this process. I have demonstrated that differences in physiological flow rates alter the fibrinolytic composition of thrombi. I developed the first model of fibrinolysis under physiological flow rates. We have shown in this model that plasminogen localizes with platelet-associated fibrino(gen) and initiates fibrinolysis. Using the Chandler model thrombi we demonstrated that free and active tPA localizes thrombus head driving fibrinolysis.

 

Cindy Neunert – Managing Anticoagulation in Ventricular Assist Devices (Clinical)

• Clinical point person for all VAD patients.

• Developed institutional protocols for all VAD devices.

• Participate in ACTION (Advanced Cardiac Therapies Improving Outcomes) Network.

• Institutional co-investigator on Berlin and Janik heart studies.

• Member of International ECMO/VAD Anticoagulation Working Group.

 

Cedric Ghevaert – From the Understanding of Platelet Biogenesis to ex vivo Platelet Production (Basic)

We have published and patented on the production of megakaryocytes and platelets from pluripotent stem cells. I am part of an EU-funded consortium called Silk Platelet that looks to translate this technology to clinical production. I am the chief investigator for a human trial with in vitro derived RFD cells.

 

Juan M. Melero-Martin – Vascular Stem Cells and Progenitors (Basic)

• My research is focused on how to build vascular networks.

• Our laboratory specializes in the biology of human blood-derived circulating endothelial colony-forming cells (ECFCs).

• Our research is focused on how to derive vascular cells from human induced pluripotent stem cell (iPSC).

• Our group has developed novel approaches to vascularize and harness the regenerative potential of various stem cells.

• Our group also developed a model that uses genetically engineered blood vessels to deliver therapeutic proteins in vivo.

 

Saskia Middeldorp – Management of (sub)Massive Pulmonary Embolism in Pregnancy (Clinical)

Management of pulmonary embolism (PE) in pregnancy is challenging. A lot of progress has been made in the diagnosis of PE in pregnancy. In this master class we will interactively discuss specific issues in a type of How I treat acute PE session.

 

Tuesday, July 12

13:15 – 14:00

 

Paolo Gresele – News in the Pathophysiology, Diagnosis and Therapeutic Approach to VITT (Basic)

• I have been working on novel approaches to platelet inhibition.

• I have studied the antithrombotic effect of the blockade of the interaction of VWF with GPIb.

• I have studied the antithrombotic role of nitric oxide-donating agents.

• I have explored the possible inhibition of platelet primers as antithrombotic approach.

• I have experience with in vitro technique and animal model in the study of antiplatelet agents.

 

Karin Leiderman – Mathematical and Computational Modeling of Blood Clotting (Basic)

Dr. Karin Leiderman is an Associate Professor of Applied Mathematics. She has an active research program focused on studying the influence of biochemical and biophysical mechanisms on blood coagulation, clot formation, and bleeding. Her research includes building, extending, and statistically analyzing mathematical and computational models of blood clotting, and validating them against experiments. This includes modeling intravascular and extravascular clotting under flow, thrombin-fibrin binding interactions, synergistic activity between clotting factors that enhances thrombin generation, and the variability in bleeding tendencies in hemophilia.

 

Kathleen Freson – Role of Genetic Screening in Hemostasis and Thrombosis (Clinical)

•  Experience in gene and variant curation for improved diagnostics of inherited hemostatic and thrombotic disorders

• Involved in diagnostics using the Whole Exome sequencing and the use of a ‘virtual panel’.

• Using Whole Genome Sequencing and platelet RNAseq for gene discoveries.

• Using megakaryocyte cell models for gene and variant characterization.

 

 

Matthew Flick – Models to Understand Non-Hemostatic Roles of Fibrin(olysis) (Basic)

I have over 20 years of experience working with animal models in which coagulation and fibrinolytic proteins have been genetically eliminated or functionally modified. The goal of my research program has been to understand the contribution of factors such as fibrinogen, plasminogen, FXIII, tPA, and UPA to inflammatory, infectious, and malignant disease through mechanism both dependent and independent on the traditional role of these proteins in hemostasis thrombosis.

 

Alexander Brill – The Inflammasome and Thrombosis (Basic)

We have been dealing with research in the field of inflammasome and thrombosis during more than six years. We have recently demonstrated tight interrelation of NLRP3 inflammasome in platelets and the release of Neutrophil Extracellular Traps (NETs). Our results show that NETs and inflammasome form a “vicious circle” supporting the development of venous thrombosis. Moreover, we identified the integral inflammasome component, caspase-1, as a promising target to prevent deep vein thrombosis. This project was funded by the British Heart Foundation and published in Blood Advances in 2021.

 

Bethany Samuelson Bannow – Managing Menorrhagia (Bleeding Disorders/Anticoagulation) (Clinical)

The main focus of my clinical and research practice is the care of women and girls with blood disorders. I have twice monthly collaborative clinic with gynecology where we see women with HMB almost exclusively. I have published research on rates of HMB in anticoagulated patients and am conducting research on bleeding in general and HMB in particular in carriers of Hemophilia A. I am also passionate about advocacy and education around menstruation and pregnancy in women with hemostatic and thrombotic disorders. I regularly give talks on this topic in regional, national and international settings and seek to provide education through social media and invited presentations for patient organizations.

 

Cristina Lo Celso – Imaging Bone Marrow Niches for Hematopoietic Stem Cells (Basic)

Prof. Lo Celso aims to understand the mechanisms regulating haematopoietic stem cell (HSC) finction during steady state and during stresses such as infections, leukaemia and transplantation. Her interdisciplinary approach combines mouse bone marrow intravital microscopy techniques, computational image analysis, molecular profiling and mathematical modelling of the HSC niche engage wider niches following exposure to mild infection. Conversely, severe Plasmodium infection leads to loss of functional HSCs, which can be reduced when specific components of the mice are targeted. The HSC nice is affected by haematological malignancies too, and Prof. Lo Celso’s publications have been cited over 5500 times; she is the first woman to have received the Foulkes medal award (2017), received the ISEH New Investigator award in 2017, presented the DGZ Carl Zeiss lecture 2018 and received the Royal Microscopical Society Life Sciences Medal 2019.

 

Peetra Magnusson – Vascular Malformations (Basic)

•  Cerebral cavernous malformations (CCM).

• Endothelial to Mesenchymal Transition (ENDMT) in CCM.

• Hemorrhage or coagulation in CCM.

• Cancer-like vasculature.

• Relevant mouse models for CCM.

 

Claire McLintock – Hormonal Treatment: Balancing Bleeding and Thrombotic Risks (Clinical)

Clinically important issue related to thrombosis on hormonal Rx. Daily questions about this in clinical life. Issues with chances of hormones with difference scenarios, personal or family history.

 

Cecilia Becattini – Managing Complex VTE Cases (Clinical)

• Clinical research on diagnosis and treatment of venous thromboembolism

• Prevention of stoke in patients with atrial fibrillation.